Pimprinols A–C,from the terrestrial actinomycete,Streptomyces sp. |
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| Authors: | Ritesh Raju Oleksandr Gromyko Viktor Fedorenko Andriy Luzhetskyy Rolf Müller |
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| Institution: | 1. Department of Microbial Natural Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, Campus C2 3, 66123 Saarbrücken, Germany;2. Department of Pharmaceutical Biotechnology, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany;3. Department of Genetics and Biotechnology of Ivan Franko National University of L’viv, Grushevskogo St. 4, L’viv 79005, Ukraine |
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| Abstract: | A Streptomyces sp. Lv3-13, isolated from the rhizosphere soil of the plant Mespilus germanica, has yielded three new pimprinine derivatives, named pimprinols A–C (1–3) and the unknown (2-aminophenyl)(2-ethyloxazol-5-yl) methanone (4) along with the known compounds 2-ethyl oxazole pimprinine and 2-propyl oxazole pimprinine. The structures of the compounds were elucidated based on spectroscopic methods including UV, HR-ESIMS and 1D, 2D NMR data. Compounds 1–4 were screened for antimicrobial and cytotoxic activities. |
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