Biogenetically related caged ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora |
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Authors: | Wei-Guang Wang Xiao-Nian Li Xue Du Ke Dong Wei Zhao Hai-Yan Wu Ling-Mei Kong Yan Li Jian-Xin Pu Han-Dong Sun |
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Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China;2. Graduate University of Chinese Academy of Sciences, Beijing 100039, PR China |
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Abstract: | Two novel caged ent-kauranoids, neolaxiflorins D (1) and E (2), along with three other new ent-kauranoids, neolaxiflorins F–H (3–5), and a known one, eriocalyxin B (6), were obtained from Isodon eriocalyx var. laxiflora. Neolaxiflorin D (1) is the first 15,16-seco-16,17-dinor-ent-kaurane diterpenoid, and neolaxiflorin E (2) is the first 15,16-seco-17-homo-ent-kauranoid. The absolute configurations of ent-kauranoids 1 and 2 were determined by single-crystal X-ray diffraction analyses. Structural analysis of intermediate compounds 3–5 indicated that eriocalyxin B (6) is a biogenetic precursor of caged ent-kauranoids 1 and 2 as illustrated. The cytotoxic activity of the new compounds was evaluated by an MTT assay. |
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