Highly chemoselective palladium-catalyzed Sonogashira coupling of 5-iodouridine-5′-triphosphates with propargylamine: a new efficient method for the synthesis of 5-aminopropargyl-uridine-5′-triphosphates |
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| Authors: | Anilkumar R Kore Annamalai Senthilvelan Muthian Shanmugasundaram |
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| Institution: | Life Technologies Corporation, Bioorganic Chemistry Division, 2130 Woodward Street, Austin, TX 78744-1832, USA |
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| Abstract: | An efficient palladium-catalyzed Sonogashira coupling of 5-iodouridine-5′-triphosphates with propargylamine is described. The catalytic reaction is highly chemoselective that affords exclusively 5-aminopropargyl-uridine-5′-triphosphates in good yields with high purities (>99.8%). |
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