Copper-catalyzed cyanation of benzyl chlorides with non-toxic K4[Fe(CN)6] |
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| Authors: | Yunlai Ren Chuanhua Dong Shuang Zhao Yanpei Sun Jianji Wang Junying Ma Chaodong Hou |
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| Affiliation: | School of Chemical Engineering & Pharmaceutics, Henan University of Science and Technology, Luoyang Henan 471003, PR China |
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| Abstract: | Copper-based catalysts were firstly introduced into the cyanation of benzyl chlorides with non-toxic K4[Fe(CN)6]. The presented method avoids the use of extremely poisonous alkali cyanides and precious palladium catalysts. No other reagent apart from CuI, K4[Fe(CN)6] and toluene was used in the cyanation, showing that the presented protocol is simple and practical. A series of benzyl chlorides were smoothly cyanated in up to 85% yield under the optimal conditions. |
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