An efficient strategy for functionalized spirolactones and dispirodihydrofuranyl oxindoles using amines and activated alkynes |
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Authors: | Selvarangam E Kiruthika Rangarajan Amritha Paramasivan T Perumal |
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Institution: | Organic Chemistry Division, Central Leather Research Institute (CSIR), Adyar, Chennai-600 020, India |
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Abstract: | A facile strategy for the synthesis of functionalized spirolactones from isatin, primary amines, and activated alkynes through Huisgen dipolar additions are discussed. A novel route for the formation of dispirodihydrofuranyl oxindoles from activated cyclic electrophiles, amines, and DMAD has also been developed. This method offers several advantages like high yield, readily available starting materials, and involves less hazardous chemical techniques. |
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