Simple and efficient synthetic routes to d-cycloserine |
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| Authors: | Hee-Kwon Kim Kyoung-Joo Jenny Park |
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| Affiliation: | 1. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA;2. Department of Chemical and Biomolecular engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA 90095, USA |
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| Abstract: | d-Cycloserine has been successfully synthesized in good yields through three new synthetic routes from a readily available d-serine. In each synthesis, cyclization served as the key step, and two of the routes employed one-pot operations for the preparation of the target product. These methods featured the use of mild reaction conditions and simple treatments. |
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