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One-pot isomerization of aldo-disaccharides to keto-disaccharides in deep sea water under sub-critical conditions |
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| Authors: | Aditya Kulkarni Makoto Ogata Takeshi Sako Taichi Usui |
| Affiliation: | 1. Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Ohya 836, Suruga ward, Shizuoka 422-8529, Japan;2. Department of Bioscience, Graduate School of Science and Technology, Shizuoka University, Ohya 836, Suruga ward, Shizuoka 422-8529, Japan;3. Department of Engineering, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu, Shizuoka 432-8561, Japan |
| Abstract: | A novel and facile one-pot isomerization of aldo-disaccharides to keto-disaccharides is achieved by making use of deep sea water in sub-critical conditions. The resulting keto-disaccharides having pharmaceutical and food applications were obtained in modest yields of about 30–32% at the optimum reaction conditions (temperature: 180 °C, reaction time: 5 min). Detailed investigation of all major ions in deep sea water revealed that bicarbonate ions play a key role as a catalyst in this isomerization reaction. |
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