Synthesis and anti-neuroinflammatory activity studies of substituted 3,4-dihydroquinoxalin-2-amine derivatives |
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| Authors: | Donthabhakthuni Shobha Murugulla Adharvana Chari Khagga Mukkanti Sun Yeou Kim |
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| Institution: | 1. Dr. MACS Bio-Pharma Pvt. Ltd, Plot-32/A, Western Hills, Kukatpally, Hyderabad 85, AP, India;2. Centre for Chemical Sciences & Technology, Institute of Science & Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 85, AP, India;3. Dept. of Applied Chemistry, Kyung Hee University, 1 Seocheon-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-701, Global campus, Suwon, Republic of Korea;4. Graduate School of East-West Medical Science, Kyung Hee University, Global Campus, #1 Seocheon-dong, Giheung-gu, Yongin, Gyeonggi-do 446-701, Republic of Korea |
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| Abstract: | We demonstrate the synthesis of multifunctional 3,4-dihydroquinoxalin-2-amine derivatives 4 through a three-component condensation reactions of a substituted o-phenylenediamines 1 (OPDA), diverse ketones 2 and various isocyanides 3 in the presence of a catalytic amount of p-toluenesulfonic acid (PTSA) affording excellent yields (82–96%) and 10 mol % of silica gel supported sulfuric acid with good yields (85–98%) in ethanol at room temperature (2–4 h). We also carried out the anti-neuroinflammatory activity of 3,4-dihydroquinoxalin-2-amine derivatives and some of the compounds exhibited good activity. |
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