Synthesis of complex fused polycyclic heterocycles utilizing IMDAF reactions of allylamino- or allyloxy-furyl(hetero)arenes |
| |
| Authors: | Matthew L Read Andreas Krapp Pedro O Miranda Lise-Lotte Gundersen |
| |
| Institution: | 1. Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N-0315 Oslo, Norway;2. Centre for Theoretical and Computational Chemistry, Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N-0315 Oslo, Norway |
| |
| Abstract: | Arenes and heteroarenes carrying a halogen and an amino- or hydroxy group have been converted to allylamino- or allyloxy-furyl-(hetero)arenes. These compounds underwent IMDAF reactions to give complex fused polycyclic heterocycles. The reactivity of the substrates was highly dependent on the detailed substitution pattern, however cyclizations occurred with high stereoselectivity in most cases. Experimental findings regarding reactivity and stereoselectivity were supported by calculations. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
