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Achillinin B and C,new sesquiterpene dimers isolated from Achillea millefolium
Authors:Yong Li  Meng-Chu Zhu  Man-Li Zhang  Yu-Fang Wang  Mei Dong  Qing-Wen Shi  Chang-Hong Huo  Françoise Sauriol  Hiromasa Kiyota  Yu-Cheng Gu  Bin Cong
Institution:1. Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, 361 Zhongshan East Road, Shijiazhuang 050017, Hebei Province, PR China;2. Department of Thoracic, Fourth Hospital of Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, Hebei Province, PR China;3. Laboratory Medical Science, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjing 212013, Jiangsu Province, PR China;4. Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, Hebei Province, PR China;5. Department of Chemistry, Queen’s University, Kingston, Ontario, Canada K7L 3N6;6. Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan;7. Syngenta Jealott’s Hill International Research Centre, Berkshire, UK
Abstract:Two novel sesquiterpene dimers, achillinin B and C, were isolated from the flowers of Achillea millefolium. The structures were elucidated by extensive spectroscopic analysis. A plausible biosynthetic pathway of achillinin B and C by Diels–Alder reaction of the corresponding guaiane sesquiterpenoids is also discussed.
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