Efficient microwave-assisted synthesis of 1-aryl-4-dimethylamino methyleno-pyrrolidine-2,3,5-triones |
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Authors: | Pâmela S Vargas Fernanda A Rosa Lilian Buriol Mariane Rotta Dayse N Moreira Clarissa P Frizzo Helio G Bonacorso Nilo Zanatta Marcos AP Martins |
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Institution: | 1. Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, 97.105-900 Santa Maria, RS, Brazil;2. Departamento de Química, Universidade Estadual de Maringá, Av. Colombo, 5790, 87.020-900 Maringá, Paraná, Brazil |
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Abstract: | A microwave-assisted synthesis of a series of 1-aryl-4-dimethylaminomethylene pyrrolidine-2,3,5-triones from the cyclocondensation reaction of ethyl 5,5,5-trichloro-3-dimethylamino methylene-2,4-dioxopentanoate with aniline, 3- or 4-substituted anilines where the substituents = 3-Me, 3-OMe, 3-OH, 4-Me, 4-F, 4-Cl, 4-Br, 4-NO2, and 4-COMe] is reported. This process is an efficient alternative to the conventional thermal heating and furnishes the products in a short reaction time (ca. 13 min), under mild conditions and in moderate to good yields (50–76%). |
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