|
|||||
|
|
Synthesis and structural study of new substituted chiral sulfamoyl oxazolidin-2-ones |
|
| Authors: | Carole Barbey Radia Bouasla Malika Berredjem Nathalie Dupont Pascal Retailleau Nour-Eddine Aouf Marc Lecouvey |
| Institution: | 1. Université Paris 13, Sorbonne Paris Cité, Laboratoire de Chimie, Structures, Propriétés de Biomatériaux et d''Agents Thérapeutiques, (CSPBAT), CNRS UMR 7244, F-93017, Bobigny, France;2. Laboratoire de Chimie Organique Appliquée, Groupe de Chimie Bioorganique, Université Badji-Mokhtar, Annaba, BP 12, Algeria;3. Service de Cristallochimie, ICSN-CNRS, Bât. 27, 1 avenue de la Terrasse, F-91 198 Gif-sur-Yvette Cédex, France |
| Abstract: | The synthesis of new series of oxazolidinones having sulfonamide moieties is described. These compounds are synthesized in good yield starting prochiral 1,3-dichloro-2-propanol and chlorosulfonyl isocyanate. This strategy involves the formation of carboxylsulfamide by carbamoylation–sulfamoylation reaction followed by intermolecular cyclization. In order to determine the enantioselectivity during the cyclization step, X-ray studies of products are performed. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |