A green one-pot synthesis of N-alkyl-2-(2-oxoazepan-1-yl)-2-arylacetamide derivatives via an Ugi four-center,three-component reaction in water |
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| Authors: | Mohammad Ali Rasouli Mohammad Mahdavi Parviz Rashidi Ranjbar Mina Saeedi Abbas Shafiee Alireza Foroumadi |
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| Affiliation: | 1. School of Chemistry, University College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran;2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran;3. Drug Design & Development Research Center, Tehran University of Medicinal Sciences, Tehran, Iran |
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| Abstract: | This work describes a green and efficient one-pot synthesis of N-alkyl-2-(2-oxoazepan-1-yl)-2-arylacetamide derivatives via an Ugi four-center, three-component reaction of 6-aminohexanoic acid, aromatic aldehydes, and isocyanide derivatives in water under reflux conditions in the absence of a catalyst. |
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