Flow microreactor synthesis of tricyclic sulfonamides via N-tosylaziridinyllithiums |
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Authors: | Eiji Takizawa Aiichiro Nagaki Jun-ichi Yoshida |
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Institution: | Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan |
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Abstract: | Tricyclic sulfonamides were synthesized by the generation of aziridinyllithiums from N-tosylaziridines followed by an intramolecular nucleophilic reaction and the subsequent reaction with electrophiles using a flow microreactor system. The reactions could be carried out at 0 °C, although much lower temperatures such as ?78 °C are needed for batch macro reactors. |
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