An efficient,expeditious, and diastereoselective one-pot pseudo-five-component reaction for the synthesis of new bis-Betti bases under catalyst-free conditions |
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Authors: | Mehdi Shafiee Ahmad R Khosropour Iraj Mohammadpoor-Baltork Majid Moghadam Shahram Tangestaninejad Valiollah Mirkhani |
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Institution: | Catalysis Division, Department of Chemistry, Faculty of Science, University of Isfahan, Isfahan 81746-7344, Iran |
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Abstract: | A novel, diastereoselective, one-pot synthesis of new bis-Betti bases via condensation of dihydroxynaphthalene, two equivalents of aryl aldehydes, and two equivalents of 3-amino-5-methylisoxazole is reported. Conversion into the adducts was almost quantitative without the use of solvent or catalyst. The reaction conditions are very simple and enable easy isolation of the product. |
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