| 3,6-二苯氧甲基-1,2,4-三唑并[3,4-b]- 1,3,4-噻二唑衍生物的合成及生物活性 |
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| 引用本文： | 孙晓红,白燕,刘源发,陈邦,贾婴琦.3,6-二苯氧甲基-1,2,4-三唑并[3,4-b]- 1,3,4-噻二唑衍生物的合成及生物活性[J].高等学校化学学报,2011,32(6):1312-1317. |
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| 作者姓名： | 孙晓红 白燕 刘源发 陈邦 贾婴琦 |
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| 作者单位： | 1. 西北大学化工学院化学研究所,
2. 化学系, 西安 710069 |
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| 摘 要： | 以4-氨基-5-苯氧甲基-3-巯基-1,2,4-三唑与取代苯氧乙酸为原料，三氯氧磷为溶剂，回流反应, 合成了3,6-二苯氧甲基-1,2,4-三唑并3,4-b]-1,3,4-噻二唑衍生物。通过IR、1H NMR和元素分析确定了各化合物分子结构，并对其进行了室内毒力测试，结果表明此类化合物具有较好的杀菌、抑菌活性。
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| 关 键 词： | 三唑 噻二唑 生物活性 |
| 收稿时间： | 2010-07-19 |
Synthesis and Biological Activities of Derivatives of 3,6-Diphenoxymethyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles |
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| SUN Xiao-Hong,BAI Yan,LIU Yuan-Fa,CHEN Bang,JIA Ying-Qi.Synthesis and Biological Activities of Derivatives of 3,6-Diphenoxymethyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles[J].Chemical Research In Chinese Universities,2011,32(6):1312-1317. |
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| Authors: | SUN Xiao-Hong BAI Yan LIU Yuan-Fa CHEN Bang JIA Ying-Qi |
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| Institution: | 1. College of Chemical Engineering, Chemical Research Institute,
2. Department of Chemistry, Northwest University, Xi’an 710069, China |
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| Abstract: | 4-amino-2,4-dihydro-5-(phenoxymethyl)-3-mercapto-3H-1,2,4-triazole and substituted phenoxyacetic acid refluxed in POCl3 to afford 3,6-diaryloxymethene -1,2,4-triazolo3,4-b]-1,3,4-thiadiazoles. The chemical structures of the compounds were confirmed by 1H NMR, IR and elemental analysis. The preliminary toxicity testing of all the target compounds were investigated. The results showed that they exhibited melt fungicidal activities. |
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| Keywords: | Triazole Thiadiazole Biological activity |
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