同轴电纺超细纤维膜构建人工血管材料

以右旋糖酐(DEX)为芯、聚乙二醇-b-聚(L-丙交酯-co-ε-己内酯)(PELCL)为壳，经同轴电纺制备DEX/PELCL超细纤维膜。在该电纺纤维内芯分别负载血管内皮生长因子(VEGF)和血小板衍生生长因子(PDGF-bb)，并以此构建双层超细纤维膜人工血管支架。4 w的释放结果表明，VEGF和PDGF-bb均表现出突释现象，含有肝素的VEGF样品释放量有所下降。大鼠腹主动脉移植实验表明，载有VEGF和PDGF-bb的超细纤维膜可以用于构建双层人工血管。

Ultrafine Fibrous Membranes by Coaxial Electrospinning for Artificial Blood Vessel

Core/shell ultrafine fibers, with dextran (DEX) and poly(ethylene glycol)-b- poly(L-lactide-co-ε-caprolactone) (PELCL) as the core and shell, respectively, were prepared by coaxial electrospinning. Double-layered ultrafine fibrous tubes of the coaxial-electrospun DEX/PELCL fibers were constructed for application as artificial blood vessel by loading vascular endothelial growth factor (VEGF) and platelet derived growth factor-bb (PDGF-bb), respectively in the fiber core. The in vitro releasing results of 4 w indicated that initial burst release occurred for both VEGF and PDGF-bb. The in vivo implantation in abdomen aorta of a rat model showed that the double-layered fibrous tubes loading VEGF and PDGF-bb could be potential used as artificial blood vessels.