131I标记海藻酸钠包裹明胶微球的制备及性能评价

建立了明胶微球和海藻酸钠(SA)包裹微球的制备方法,并通过实验比较了明胶微球和包裹微球的各种特性,最后用氯胺T法将125I及131I分别标记在微球上.结果表明,包裹微球对碘有更高的负载量和稳定性;在相同条件下,包裹微球的降解时间比明胶微球的降解时间长;将标记后的明胶微球通过直接注射介入到新西兰大白兔的肝脏,采用发射单光...

Preparation and Bio-Evaluation of Iodine Labelling Gelatin Microspheres and the Coating Microspheres with Sodium Alginate

This paper describes a method to prepare the gelatin microspheres and the wrapped microspheres with sodium alginate（SA）. The microspheres were labeled with iodine-131,125 by Chloramine-T method and followed by injecting into the liver of rabbits. The characteristic comparisons of the gelatin microspheres and the wrapped microspheres were made and the results indicated that the wrapped microspheres can have a more iodine loading capacity and better stability than the gelatin microspheres. It also appeared that the degradation rate of wrapped microspheres is slower than the gelatin microspheres in physical condition. As a matter of fact the stability of iodine-131 in gelatin microspheres in the rabbits was evidenced by the ECT visualization: no visible radio-speck at the position of thyroid gland has been observed by injecting the wrapped microspheres, while the noticeable radio-speck of thyroid gland has been observed at the same site by injection of the gelatin microspheres, which proved that 131I in wrapped gelatin microsphere has better stability than in the gelatin microspheres.