Stereo/regio-controlled cyclization of polychlorohex-5-enoic acids into substituted cyclobutanes |
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Authors: | A R Mikaelyan |
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Institution: | 1.Armenian State Engineering University (Polytechnic),Yerevan,Armenia |
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Abstract: | A new method of synthesis was developed for functionally substituted cyclobutanecarboxylic acids based on an intramolecular
cyclization of derivatives of the 2,2,4,6,6-pentachloro-3,3-dimethylhex-5-enoic acid in the presence of the copper(I) amine
complexes. The cyclization proceeds both regiospecifically and stereoselectively, and the stereoisomeric composition of the
products depends on the capability of the functional group in the initial polychloroalkenoic acid to coordinate to the transition
metal ion. A reaction mechanism is suggested explaining the region/stereo-controlled course of the cyclization process. |
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Keywords: | |
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