不对称Kabachnik-Fields反应合成研究进展

不对称三组分Kabachnik-Fields反应合成光学活性的α-氨基膦酸酯,由于其多组分反应自身所具有的独特优势,近年来已成为一个非常有吸引力的研究领域.从手性催化剂催化和光学活性底物诱导两方面综述了不对称Kabachnik-Fields反应合成手性α-氨基膦酸酯及其衍生物的最新研究进展,重点介绍了手性催化剂与手性底物构型对反应立体选择性的影响及其有关反应机理.最后提出了不对称多组分Kabachnik-Fields反应研究中存在的一些问题,并对其今后的发展方向进行了展望.

Recent Progress in Asymmetric Synthesis of Kabachnik-Fields Reaction

Asymmetric three-component Kabachnik-Field reaction for the stereoselective synthesis of optically active α-amino phosphonates has been received considerable attention due to their great intrinsic advantages as well as their applica-tions in drug discovery.This review covers recent progress on asymmetric three-component Kabachnik-Field reaction includ-ing the chiral catalysts and optical active substrate induction approaches to chiral α-aminoalkylphosphonic acid derivatives.The influence of the chiral catalysts and reaction substrate configuration on the reaction stereoselectivity is the major focus.It elicits issues and perspectives of asymmetric three-component Kabachnik-Field reaction in the end.