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| 无溶剂条件下方便、有效的方法合成3-氰基-2-吡啶酮衍生物 | |
| 引用本文： | 荣良策,刘丽华,殷姗,夏盛,魏贤勇,宗志敏.无溶剂条件下方便、有效的方法合成3-氰基-2-吡啶酮衍生物[J].有机化学,2012,32(2):400-403. |
| 作者姓名： | 荣良策 刘丽华 殷姗 夏盛 魏贤勇 宗志敏 |
| 作者单位： | 1. 中国矿业大学化工学院 徐州221008;徐州师范大学化学化工学院 徐州221116 2. 中国矿业大学化工学院 徐州221008 3. 徐州师范大学化学化工学院 徐州221116 |
| 基金项目： | 江苏省高校自然科学基础研究基金，徐州师范大学科研平台 |
| 摘 要： | 芳醛、丙酮和氰乙酰胺为原料,氢氧化钠为催化剂,在无溶剂条件下加热反应有效地合成2-吡啶酮衍生物,本方法具有反应时间短、条件温和、处理简单和环境友好等优点. |
| 关 键 词： | 2-吡啶酮 杂环 无溶剂反应 合成 |
A Facile and Efficient Synthesis of 3-Carbonitrile Pyridin-2(1H)-one Derivatives under Solvent-Free Conditions |
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| Rong, Liangce , Liu, Lihua , Yin, Shan , Xia, Sheng , Wei, Xianyong , Zong, Zhimin.A Facile and Efficient Synthesis of 3-Carbonitrile Pyridin-2(1H)-one Derivatives under Solvent-Free Conditions[J].Chinese Journal of Organic Chemistry,2012,32(2):400-403. | |
| Authors: | Rong Liangce Liu Lihua Yin Shan Xia Sheng Wei Xianyong Zong Zhimin |
| Institution: | Rong,Liangce*,a,b Liu,Lihuaa Yin,Shanb Xia,Shengb Wei,Xianyong*,a Zong,Zhimina(a School of Chemical Engineering and Technology,China University of Mining and Technology,Xuzhou 221008)(b College of Chemistry and Chemical Engineering,Xuzhou Normal University Xuzhou 221116) |
| Abstract: | An efficient and convenient method for the preparation of 3-carbonitrile pyridin-2(1H)-one derivative by the one-pot reaction of aromatic aldehydes,acetones and 2-cyanoacetamide in the presence of sodium hydroxide under sol-vent-free condition was reported.This method has the advantages of excellent yields,mild reaction conditions,easy work-up,and environmentally friendly procedure. |
| Keywords: | pyridin-2(1H)-one heterocycle solvent-free reaction synthesis |
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