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| 无溶剂条件下简单、有效地合成1,6-二氢嘧啶-6-酮衍生物 | |
| 引用本文： | 刘丽华,殷姗,夏盛,蔡佩君,荣良策.无溶剂条件下简单、有效地合成1,6-二氢嘧啶-6-酮衍生物[J].有机化学,2012,32(3):612-615. |
| 作者姓名： | 刘丽华 殷姗 夏盛 蔡佩君 荣良策 |
| 作者单位： | 1. 中国矿业大学化工学院 徐州221008 2. 徐州师范大学化学化工学院 徐州221116 3. 中国矿业大学化工学院 徐州221008;徐州师范大学化学化工学院 徐州221116 |
| 基金项目： | 江苏省高校自然科学基础研究基金(No.08KJB150017);徐州师范大学科研平台(No.10XLS02)资助项目~~ |
| 摘 要： | 以芳醛、氰乙酸乙酯和碳酸胍为原料,氢氧化钠-碳酸钾为催化剂,在无溶剂条件下70℃反应有效地合成了1,6-二氢嘧啶-6-酮衍生物,本方法具有反应时间短、条件温和、处理简单和环境友好等优点.通过红外、核磁、高分辨质谱和晶体的X衍射确定产物的结构. |
| 关 键 词： | 1 6-二氢-6-嘧啶酮 杂环化合物 无溶剂反应 |
A Facile and Efficient Synthesis of 1,6-Dihydro-6-oxo-pyrimidine Derivatives under Solvent-Free Conditions |
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| Liu, Lihua , Yin, Shan , Xia, Sheng , Cai, Peijun , Rong, Liangce.A Facile and Efficient Synthesis of 1,6-Dihydro-6-oxo-pyrimidine Derivatives under Solvent-Free Conditions[J].Chinese Journal of Organic Chemistry,2012,32(3):612-615. | |
| Authors: | Liu Lihua Yin Shan Xia Sheng Cai Peijun Rong Liangce |
| Institution: | Liu,Lihuaa Yin,Shanb Xia,Shengb Cai,Peijun,a Rong,Liangce,a,b(aSchool of Chemical Engineering and Technology,China University of Mining and Technology,Xuzhou 221008)(bCollege of Chemistry and Chemical Engineering,Xuzhou Normal University,Xuzhou 221116) |
| Abstract: | An efficient and facile synthesis of 2-amino-1,6-dihydro-6-oxo-pyrimidine derivatives via reaction of aromatic aldehydes,ethyl 2-cyanoacetate and guanidine carbonate by using NaOH and K2CO3 as catalyst under solvent-free conditions at about 70 ℃ is reported.This protocol has the advantages of shorter time,mild conditions,easy work-up and environmental friendliness.The products were identified by IR,1H NMR and HRMS techniques,and that of 4e was additionally confirmed by X-ray diffraction analysis. |
| Keywords: | 6-oxo-pyrimidine heterocyclic compound solvent-free reaction |
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