| 具有表皮生长因子受体抑制活性的喹唑啉衍生物研究进展 |
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| 引用本文： | 张英,王培义,胡德禹,金林红,杨松. 具有表皮生长因子受体抑制活性的喹唑啉衍生物研究进展[J]. 有机化学, 2012, 32(3): 444-461 |
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| 作者姓名： | 张英 王培义 胡德禹 金林红 杨松 |
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| 作者单位： | 贵州大学精细化工研究中心 绿色农药与农业生物工程国家重点实验室培育基地与教育部重点实验室 贵阳550025 |
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| 基金项目： | 国家重点基础研究发展计划(973)(Nos.2010CB126105,2010CB134504);国家自然科学基金(No.21172048);国家科技支撑计划课题(Nos.2011BAE06B02,2011BAE06B05)资助项目~~ |
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| 摘 要： | 综述了近十年来具有表皮生长因子受体(EGFR)抑制活性的喹唑啉衍生物的国内外研究进展,按照喹唑啉环上不同位置上的取代基类型分为四类,介绍了化合物不同位置上取代基对此类化合物生物活性的影响,并对其发展趋势和应用前景作了展望.
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| 关 键 词： | 表皮生长因子受体 喹唑啉 生物活性 |
Research Progress on Quinazoline Derivatives with Epidermal Growth Factor Receptor Inhibiting Bioactivity |
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| Zhang, Ying , Wang, Peiyi , Hu, Deyu , Jin, Linhong , Yang, Song. Research Progress on Quinazoline Derivatives with Epidermal Growth Factor Receptor Inhibiting Bioactivity[J]. Chinese Journal of Organic Chemistry, 2012, 32(3): 444-461 |
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| Authors: | Zhang Ying Wang Peiyi Hu Deyu Jin Linhong Yang Song |
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| Affiliation: | Zhang,Ying Wang,Peiyi Hu,Deyu Jin,Linhong Yang,Song(State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering,Center for Research and Development of Fine Chemicals,Guizhou University,Guiyang 550025) |
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| Abstract: | The progress on quinazoline derivatives with epidermal growth factor receptor(EGFR) inhibiting bioactivity is reviewed in this paper.Quinazoline compounds are classified to four types according to different substituent groups at different ring position.The effects of substituent groups at different ring positions on the bioactivities are discussed.And the development tendency as well as the prospect of quinazoline derivatives as epidermal growth factor receptor tyrosine kinase inhibitors is summarized. |
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| Keywords: | epidermal growth factor receptor quinazoline bioactivity |
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