| 4-(7-甲氧基-2,2-二甲基-2,3-二氢苯并呋喃-5-基)-2-苄亚氨基噻唑的合成与生物活性 |
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| 引用本文： | 沈芳,胡艾希,罗先福,叶姣,欧晓明.4-(7-甲氧基-2,2-二甲基-2,3-二氢苯并呋喃-5-基)-2-苄亚氨基噻唑的合成与生物活性[J].有机化学,2012,32(2):388-392. |
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| 作者姓名： | 沈芳 胡艾希 罗先福 叶姣 欧晓明 |
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| 作者单位： | 1. 湖南大学化学化工学院 长沙410082
2. 湖南化工研究院 长沙410007 |
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| 摘 要： | 呋喃酚经醚化、傅克酰化、α-溴代、噻唑环化和亚胺化等反应合成了16种4-(7-甲氧基-2,2-二甲基-2,3-二氢苯并呋喃-5-基)-2-苄亚氨基噻唑新化合物.化合物的结构经1H NMR、质谱和元素分析等确证.杀虫活性实验结果表明,化合物2a和2i在500 mg/L对棉红蜘蛛死亡率分别为53.10%和67.71%,杀菌活性实验结果表明,化合物2a和2k在25 mg/L对油菜菌核病菌抑制率分别为57.9%和59.8%,除草活性实验结果表明,2l在2250 g.ai/ha浓度下对苘麻、刺苋、藜具有一定的除草活性.
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| 关 键 词： | 4-(7-甲氧基-2 2-二甲基-2 3-二氢苯并呋喃-5-基)-2-苄亚氨基噻唑 合成 杀虫活性 杀菌活性 除草活性 |
Synthesis and Bioactivity of (E)-2-Benzylidenimino-4-(7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)thiazole |
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| Shen, Fang
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Hu, Aixi
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Luo, Xianfu
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Ye, Jiao
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Ou, Xiaoming.Synthesis and Bioactivity of (E)-2-Benzylidenimino-4-(7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)thiazole[J].Chinese Journal of Organic Chemistry,2012,32(2):388-392. |
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| Authors: | Shen Fang Hu Aixi Luo Xianfu Ye Jiao Ou Xiaoming |
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| Institution: | Shen,Fanga Hu,Aixi*,a Luo,Xianfua Ye,Jiaoa Ou,Xiaoming*,b(a College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082)(b Hunan Research Institute of Chemical Industry,Changsha 410007) |
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| Abstract: | Sixteen(E)-2-benzylidenimino-4-(7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)thiazoles were synthesized from 2,3-dihydro-2,2-dimethyl-7-benzofuranol by etherification,Friedel-Crafts acylation,α-bromation,cyclization of thiazole and imidization.Their structures were clearly established by 1H NMR,MS spectra and elemental analysis.The preliminary bioassays indicated that compounds 2a and 2i exhibited insecticidal activity against T.urticae were 53.10% and 67.71% at 500 mg/L.Compounds 2a and 2k exhibited fungicidal activity against S.sclerotiorum were 57.9% and 59.8% at 25 mg/L.Com-pound 2l showed different degrees of herbicidal activity against A.theophrasti,A.spinosus L and C.album at 2250 g.ai/ha. |
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| Keywords: | (E)-2-benzylidenimino-4-(7-methoxy-2 2-dimethyl-2 3-dihydrobenzofuran-5-yl)thiazole synthesis insecticidal activity fungicidal activity herbicidal activity |
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