High resolution electrospray ionization ion mobility spectrometry |
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Authors: | Clinton A Krueger Christopher K Hilton Mark Osgood Jianglin Wu Ching Wu |
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Institution: | (1) Excellims Corporation, 20 Main Street Action, Acton, MA 01720, USA |
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Abstract: | Current commercially available ion mobility spectrometers are intended for the analysis of chemicals in the gas phase. Sample
introduction methods, such as direct air sampling, a GC injector or a thermal desorber, are commonly an integral part of these
instruments. This paper describes an electrospray ionization ion mobility spectrometer system that allows direct introduction
samples in solution phase. This allows direct analysis of non-volatile organic and biological samples, and avoids decomposition
of thermally liable samples, providing reliable chemical identification. In addition, the new ion mobility spectrometer allows
mobility analysis with high resolving power. Commonly used commercial IMS systems provide resolving powers between 10 and
30; this new ion mobility spectrometer has resolving power greater than 60 for routine analysis. A high resolution instrument
is necessary for many applications where a complex mixture needs to be separated and quantified. This paper demonstrates the
advantages of using a high resolution ion mobility spectrometer and an electrospray ionization source for the analysis of
non-volatile pharmaceuticals as well as dissolved explosive in solution phase. |
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Keywords: | Ion mobility spectrometry Electrospray ionization High resolution Pharmaceuticals Explosives Irinotecan |
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