Semi-synthesis of a protease-activatable collagen targeting probe |
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| Authors: | Breurken Monica Lempens Edith H M Meijer E W Merkx Maarten |
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| Institution: | Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. |
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| Abstract: | A protease-activatable collagen targeting probe (proCNA35) is synthesized by conjugation of a synthetic collagen fragment to the collagen binding protein CNA35 via a protease-cleavable linker. Cleavage of the linker by MMP1 releases the intramolecular inhibition of the collagen binding site and restores its collagen binding capacity. |
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