The fluorous effect in biomolecular applications |
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Authors: | Cametti Massimo Crousse Benoit Metrangolo Pierangelo Milani Roberto Resnati Giuseppe |
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Institution: | NFMLab-DCMIC Giulio Natta, Politecnico di Milano, via Mancinelli 7, I-20131 Milan, Italy. |
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Abstract: | From being a niche area only a few decades ago, fluorous chemistry has gained momentum and is, nowadays, a fervent area of research. It has brought forth, in fact, numerous applicative innovations that stretch among different fields: from catalysis to separation science, from supramolecular to materials and analytical chemistry. Recently, the unique features of perfluorinated compounds have reached the attention of the biochemists' audience. This tutorial review introduces the basic concepts of fluorous chemistry and illustrates its main biomolecular applications. Special attention has been given to fluorous microarrays and their combination with Mass-Spectroscopy (MS) techniques, to protein properties modification by the introduction of local fluorous domains, and to the most recent applications of (19)F-Magnetic Resonance Imaging ((19)F-MRI). |
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