New uniform algorithm to predict reversed phase retention values under different gradient conditions |
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Authors: | Wang Longxing |
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Institution: | Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 129 Street, P.O. Box 100, Dalian 116012, PR China |
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Abstract: | A new numerical emulation algorithm was established to calculate retention parameters in RP-HPLC with several retention times under different linear or nonlinear binary gradient elution conditions and further predict the retention time under any other binary gradient conditions. A program was written according to this algorithm and nine solutes were used to test the program. The prediction results were excellent. The maximum relative error of predicted retention time was less than 0.45%. |
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Keywords: | Reversed phase HPLC Retention parameter Algorithm Gradient elution |
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