First synthesis of 2',3'-epimino-carbocyclic nucleosides |
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| Authors: | Ishikura Minoru Murakami Atsushi Katagiri Nobuya |
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| Institution: | Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan. ishikura@hoku-iryo-u.ac.jp |
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| Abstract: | The preparation of 2',3'-epimino-carbocyclic analogues of adenosine is reported. The reaction of p-tosyl azide with N-substituted 2-azabicyclo2.2.1]hept-5-en-3-one (ABH) (1a) provided aziridine-fused ABH (2), which was converted to 2',3'-epimino-carbocyclic nucleosides (11). |
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