Deuterated analogues of the free radical trap DEPMPO: synthesis and EPR studies |
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Authors: | Clément Jean-Louis Finet Jean-Pierre Fréjaville Claudine Tordo Paul |
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Institution: | Laboratoire SREP, UMR 6517 CNRS et Universités d'Aix-Marseille 1 et 3, Case 521, Avenue Escardrille Normandie-Niemen, 13397 Marseille, France. clement@srepir1.univ-mrs.fr |
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Abstract: | Three analogues of 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO, 1) labelled with two (1-d2), five (1-d5) or seven (1-d7)2H were synthesized and used to trap the tert-butylperoxyl radical. The EPR spectra of 1-d2-OOBu(t) and 1-d7-OOBu(t) spin adducts exhibited more straightforward patterns and better signal to noise ratio than those obtained with 1 or 1-d5. The use of the easily available 1-d2 as spin trap could help significantly the analysis of the EPR signals when the signal of either superoxide or alkylperoxyl spin adduct is superimposed with the signals of other spin adducts. |
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