Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum) |
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| Authors: | Kim Nam-Cheol Graf Tyler N Sparacino Charles M Wani Mansukh C Wall Monroe E |
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| Institution: | Natural Product Laboratory, Chemistry and Life Sciences, Research Triangle Institute, 3040 Cornwallis Road, Research Triangle Park, North Carolina 27709, USA. nck@rti.org, mcw@rti.org |
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| Abstract: | Complete separation, isolation, and structural characterization of four diastereoisomeric flavonolignans, silybins A (1) and B (2), and isosilybins A (3) and B (4) from the seeds of milk thistle (Silybum marianum) were achieved for the first time using a preparative reversed-phase HPLC method. In addition, three other flavonolignans, silychristin (5) isosilychristin (6) and silydianin (7), and a flavonoid, taxifolin (8) were isolated. Structures, including absolute stereochemistries of 1-4, were confirmed using 2D NMR and CD spectroscopy. |
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