Asymmetric hydrogenation of a 4,4-diaryl-3-butenoate; a novel approach to sertraline |
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| Authors: | Boulton Lee T Lennon Ian C McCague Raymond |
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| Institution: | Dowpharma, Chirotech Technology Limited, Dow Chemical Company, Cambridge Science Park, Unit 321, Milton Road, Cambridge, UK CB4 0WG. lboulton@dow.com |
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| Abstract: | The asymmetric hydrogenation of a selectively crystallised (E)-4,4-diaryl-3-butenoate with a rhodium-PhanePhos catalyst is described, providing an intermediate to the antidepressant sertraline. |
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