Total synthesis of (+/-)-rhazinal,an alkaloidal spindle toxin from Kopsia teoi |
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| Authors: | Banwell Martin G Edwards Alison J Jolliffe Katrina A Smith Jason A Hamel Ernest Verdier-Pinard Pascal |
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| Institution: | Research School of Chemistry, Institute of Advanced Studies, Australian National University, Canberra, ACT 0200, Australia. mgb@rsc.anu.edu.au |
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| Abstract: | The title alkaloid 1 and its B-nor-congener 3, both of which display potent and unusual anti-mitotic properties, have been synthesized in racemic form and characterised by single-crystal X-ray analysis. |
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