First total synthesis of louisianin A |
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| Authors: | Chang Ching-Yao Liu Hui-Ming Chow Tahsin J |
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| Institution: | Department of Biotechnology and Bioinformatics, Asia University, Wufeng, Taichung, 413, Taiwan, Republic of China. cychang@asia.edu.tw |
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| Abstract: | The first total synthesis of louisianin A, 4-allyl-6,7-dihydro-1-hydroxycyclopentac]pyridin-5-one, is achieved from 2-chloro-4-cyanopyridine 5 via seven steps in an overall 24% yield. The key step is a cyclization-decarboxylation sequence toward the formation of a cyclopentenone ring. |
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