First total synthesis of salinipyrone A using highly stereoselective vinylogous Mukaiyama aldol reaction期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

First total synthesis of salinipyrone A using highly stereoselective vinylogous Mukaiyama aldol reaction

Authors:	Palakuri RameshHarshadas Mitaram Meshram

Affiliation:	Natural Product Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India

Abstract:	A synthetic approach for the total synthesis of salinipyrone A has been developed. Key steps involve the TiCl₄-mediated vinylogous Mukaiyama aldol reaction (VMAR) of chiral ketene silyl N,O-acetal with propionaldyhyde, an aldol condensation, Witting olefination, and a cyclization. The synthesis proceeds in eight steps.

Keywords:	Aldol reaction Wittig olifination Cyclization Salinipyrones Pacificanones
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