A facile and efficient procedure for the synthesis of new benzimidazole-2-thione derivatives |
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Authors: | Augusto Rivera Mauricio Maldonado Jaime Ríos-Motta |
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Institution: | Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Cra.30 No.45-03, Bogotá 111321, Colombia. ariverau@unal.edu.co |
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Abstract: | A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzod,i]-1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, 1H-, 13C-NMR and GC-MS analyses of the new compounds is provided. These compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form in 15%-51.4% yield. |
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