Cell-penetrating peptides as delivery vehicles for a protein-targeted terbium complex |
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| Authors: | Shabnam Mohandessi Megha Rajendran Darren Magda Lawrence W Miller |
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| Institution: | Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607 (USA), Fax: (+1)?312-996-0431. |
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| Abstract: | Release after transmission: Arginine-rich, cell-penetrating peptides (CPPs) mediate cytoplasmic delivery of trimethoprim (TMP)-terbium complex conjugates and selective, intracellular labeling of E.?coli dihydrofolate reductase (eDHFR) fusion proteins. A disulfide bond linking CPP and cargo is reduced following uptake. CPP conjugation can be used to deliver otherwise cell-impermeable, ligand-fluorophore conjugates. |
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