Targeted thiazole orange derivative with folate: synthesis, fluorescence and in vivo fluorescence imaging |
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Authors: | Fei Xuening Gu Yingchun Wang Yiqi Meng Qingyang Zhang Baolian |
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Institution: | School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. xueningfei@126.com |
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Abstract: | A Thiazole Orange conjugated with folate derivative was synthesized in two steps. Firstly, folate was coupled with 1-(3-aminopropyl)-4-methylquinolinium bromide to afford folate-methylquinolinium bromide, which then reacted with benzothiazolium to obtain the title folate-conjugated compound. The compound was evaluated by 1H-NMR MS, TG/DTA and fluorescence spectroscopic methods. The title compound could selectively target folate receptor expressing tumors according to the in vivo fluorescence imaging preliminarily performed on nude mice with breast tumors. |
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