Synthesis 1-acyl-3-(2'-aminophenyl) thioureas as anti-intestinal nematode prodrugs |
| |
Authors: | Duan Li-Ping Xue Jia Xu Li-Li Zhang Hao-Bing |
| |
Affiliation: | National Institute for Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China. |
| |
Abstract: | A series of 1-acyl-3-(2'-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, 1H-NMR and 13C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were evaluated in rats by an oral route. Among these compounds, at concentrations of 10 mg/kg of rat, compound (1-(2'-furanyl)acyl-3- (2'-aminophenyl) thiourea) produced the highest activity with 89.4% deparasitization. The present work suggests that 1-acyl-3-(2'-aminophenyl) thiourea derivatives may become useful lead compounds for anti-intestinal nematode treatment. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|