A novel C3-symmetric prolinol-squaramide catalyst for the asymmetric reduction of ketones by borane |
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Authors: | Xiang-Fei Wu Chang Min Enkhtsetseg Nyamzundui Hai-Bing Zhou Chune Dong |
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Affiliation: | State Key Laboratory of Virology, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China |
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Abstract: | A novel C3-symmetric prolinol-squaramide has been developed for the asymmetric reduction of ketones by borane. By using only 5 mol % catalyst 1a for the reaction, high yields and excellent enantioselectivities (up to 95% yield, 93% ee) were obtained. Moreover, 1a can be easily recovered by simple precipitation and re-used for four cycles without losing the selectivity. |
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