MECHANISM OF INTERFERON ACTION Ⅹ——ANTAGONISTIC EFFECT OF ATP ON pppA2'p5'A2'p5'A RECEPTOR |
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引用本文: | 李世武,刘新垣.MECHANISM OF INTERFERON ACTION Ⅹ——ANTAGONISTIC EFFECT OF ATP ON pppA2''''p5''''A2''''p5''''A RECEPTOR[J].中国科学B辑(英文版),1988(3). |
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作者姓名: | 李世武 刘新垣 |
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作者单位: | Shanghai Institute of Biochemistry,Academia Sinica,Shanghai Institute of Biochemistry,Academia Sinica |
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摘 要: | pppA2'p5'A2'p5'A (2'-5'P_3A_3) receptor may be the first one in the oligonucleotide field.But ATP can compete with 2'-5'P_3A_3 for the receptor. This raises a question whether this is anATP receptor. If not, what is the role of ATP for this receptor? Data available in this arti-cle show that ATP can bind to macrophages with saturability and reversibility. So ATPappears to be also a ligand of the receptor for 2'-5'P_2A_3. But the binding of ATP did notdevelop phagocytic effect as mentioned before~(11]). Moreover, ATP inhibited the enhancementof phagocytosis of macrophages by 2'-5'P_3A_3 when it acted together with 2'-5'P_3A_3 on mac-rophages at the same time. It is concluded that ATP is an antagonist of 2'-5'P_3A_3 receptor.When macrophages were treated with ATP prior to 2'-5'P_3A_3 and the binding sites for 2'-5'P_3A_3P were first occupied by ATP, both the binding ability and the biological effect of2'-5'P_3A_3 were all markedly blocked. The above data convincingly show that the action of2'-5'P_3A_3 is
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