1. School of Pharmaceutical Sciences, Kitasato University, Shirokane, Minato‐ku, Tokyo 108‐8641, Japan;2. Center for Natural Sciences, Kitasato University, Kitasato, Sagamihara, Kanagawa 228‐8555, Japan;3. Department of Chemistry, Catholic University of Taegu, Gyongsan 712‐702, Korea
Abstract:
The reaction of 7‐chloro‐1‐methylpyridazino3,4‐b]quinoxalin‐4(1H)‐ones 3a‐5a with sodium methylthiolate gave 1‐methyl‐7‐methylsulfanylpyridazino3,4‐b]quinoxalin‐4(1H)‐ones 8a‐c , whose reaction with m‐chloroperbenzoic acid afforded the 7‐methanesulfonyl‐1‐methylpyridazino3,4‐b]‐quinoxalin‐4(1H)‐ones 9a‐c , respectively. The above substituent change at the 7‐position resulted in the activity alteration to microorganisms.
