1. Chemistry Department;2. Faculty of Science;3. Fayoum University;4. Fayoum;5. A. R. Egypt;6. Cairo University;7. Giza
Abstract:
3‐Substituted acylindoles 8 are obtained via refluxing carboxylic acids with indole in acetic anhydride solutions. The formed 3‐substituted acylindole 8a is readily converted into 4‐aminopyrazol‐3‐ylindoles 20 , and into 22 . Indole reacts with chloroacetyl chloride to yield: 3‐chloroacetylindole 9 which could also be utilized for synthesis of a number of 3‐substituted indoles.