1. Department of Nuclear Science, National Tsing‐Hua University, No. 101, Sec. 2, Guang‐Fu Road, Hsinchu 300, Taiwan, R.O.C.;2. Chang Bing Memorial Hospital, No. 6, Lu‐Gung Road, Chang‐Hua County 505, Taiwan, R.O.C.
Abstract:
Tumor cells transduced with herpes simplex virus thymidine kinase gene have been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facile preparation of 5‐[125I] iodoarabinosyl uridine starting from commercially available uridine is reported herein.