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Synthesis of 5‐(6‐Pyridazinone‐3‐yl)‐2‐Glycosylamino‐1,3,4‐Oxadiazoles
Authors:Jing Tao  Duo‐Zhi Wang  Ling‐Hua Cao
Institution:1. Department of Chemistry, Xinjiang University, Urumqi Xinjiang, 830046, P. R. China;2. State Key Laboratory of Elemento‐organic Chemistry, Nankai University, Tianjin, 300071, P. R. China
Abstract:N‐Glycosyl‐2‐(1,4,5,6‐tetrahydropyridazin‐6‐one‐3‐carbonyl)‐hydrazinecarbothioamides 3a‐3g and N‐glycosyl‐2‐(1,6‐dihydropyridazin‐6‐one‐3‐carbonyl)‐hydrazinecarbothioamides 5a‐5g were prepared by the reaction of glycosyl isothiocyanates with the compounds 1,4,5,6‐tetrahydro‐3‐hydrozinecarbonyl‐6‐pyridazinone ( 1 ) and 1,6‐dihydro‐3‐hydrozinecarbonyl‐6‐pyridazinone ( 2 ). The terminal heterocyclic compounds 1,3,4‐oxadiazole derivatives were obtained from cyclization of compounds ( 3a‐3g ) and ( 5a‐5g ) by mercuric acetate. Their structures were confirmed by IR, 1H NMR, MS and elemental analyses.
Keywords:Pyridazinone  Thiosemicarbazide  1  3  4‐Oxadiazole
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