1. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, 44100 Ferrara, Italy;2. NicOx Research Institute, 20091 Bresso, Milano, Italy;3. Department of Chemistry, Faculty of Science, Assiut University, 71516 Assiut, Egypt;4. Departamento de Química Farmacéutica y Orgánica, Campus Universitario de Cartuja s/n, Universidad de Granada, 18071 Granada, Spain;5. Dipartimento di Medicina Clinica e Sperimentale‐Sezione di Farmacologia, Università di Ferrara, 4100 Ferrara, Italy
Abstract:
The reaction between 3‐(dimethylamino)/3,3‐bis(methylthio)‐1‐(substituted)prop‐2‐en‐1‐ones and 4‐substituted‐5‐amino‐1H‐pyrazoles afforded new pyrazole[1,5‐a]pyrimidines structurally related to Zaleplon. The chemical modifications introduced at the 3‐, 5‐, and 7‐positions of the bicyclic structure revealed new promising candidates for the treatment of sleep disorders.