Development a New Method for the Determination of Chloropromazine in Trace Amounts by Fast Fourier Continuous Cyclic Voltammetry at an Au Microelectrode in a Flowing System

In this study a new technique has been developed for the determination of chloropromazine in flow‐injection systems. The technique, named fast Fourier transformation continuous cyclic voltammetry (FFTCV), basically illustrates the benefits of sensitivity, selectivity, simplicity and low detection limit. It is also important to refer to the positive points, presented only by the use of this technique. Firstly, it is no longer necessary to remove the oxygen from the test solution. Furthermore, the quick determination of any such compound in many chromatographic methods is possible. Thirdly, the corresponding detection limit is of sub‐nanomolar level. Additionally, a special computer based numerical method is also introduced for the calculation of the analyte signal and noise reduction. The electrode response was calculated in accordance with the partial and total charge exchanges on the electrode surface, after the background current subtraction from that of noise. The integration range of currents was set for all the potential scan ranges, including oxidation and reduction of Au surface electrode, to obtain a sensitive determination. The performed experiments aimed at measuring the effects of different parameters on the method sensitivity. In the end of these measurements, it was concluded that the method was linear for the concentration range of 0.32–31900 pg/mL (r = 0.996) with a limit of detection and quantitation 0.1 and 0.32 pg/mL, respectively. For the achievement of these optimum results, the parameter values were set to 100 V/s for the scan rate, 0.4 s for accumulation time, 800 mV for accumulation potential and 2 for the pH.