1. Chemical Research Department, APL Research Center, A division of Aurobindo Pharma ltd, Hyderabad‐500 072, Andhra Pradesh, India;2. Jawaharlal Nehru Technological University, Kukatpally, Hyderabad‐500 072, India
Abstract:
A simple one pot synthetic method for the isomerization of cephem double bond from the natural 3‐position to 2‐cephem positions is affected by silylation. Thus cephalosporin acids are treated with Ntrimethylsilylacetamide (MSA) or N,O‐bis(trimethylsilyl)acetamide (BSA) and the resulting silyl esters are treated with triethylamine at ambient temperature in the same pot to afford Δ2‐cephalosporins, which are potentially related compounds in cephalosporin antibacterial compounds.
