Organic Chemistry Department, Chemistry & Chemical Engineering Research Center of Iran, P.O.Box 14335‐186, Tehran, Iran
Abstract:
A remarkably efficient double crossed aldol condensation of piperidin‐4‐one with various aromatic aldehydes is described at room temperature in the presence of diethylamine and lithium perchlorate under solvent‐free conditions. Excellent yields of 3,5‐bis(arylmethylidene)piperidinones are achieved in a facile one‐pot general procedure. Structure of the products is determined by spectroscopic methods and elemental analysis.
