含氮亲核试剂在2-甲磺酰基-5-(3,4,5-三甲氧基苯基)-1,3,4-恶二唑环上取代反应的研究 |
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引用本文: | 冯小明,陈荣,林涛. 含氮亲核试剂在2-甲磺酰基-5-(3,4,5-三甲氧基苯基)-1,3,4-恶二唑环上取代反应的研究[J]. 有机化学, 1994, 14(3): 293-299 |
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作者姓名: | 冯小明 陈荣 林涛 |
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作者单位: | 中国科学院成都有机化学研究所;西南师范大学化学系 |
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摘 要: | 本文报道了制备2-甲磺酰基-5-(3,4,5-三甲氧基苯基)-1,3,4-恶二唑和其进一步与多种亲核试剂反应. 2-巯基-5-(3,4,5-三甲氧基苯基)-1,3,4-恶二唑经过甲基化, 而后用KMnO~4氧化得到2-甲磺酰基-5-(3,4,5-三甲氧基苯基)-1,3,4-恶二唑衍生物. 其结构由元素分析,IR, ^1H NMR 和MS确定.化合物4对大肠杆菌和枯草芽孢杆菌有较强的抑制性能.
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关 键 词: | 酰肼 四唑 P 亲核试剂 杀菌活性 亲核取代反应 恶二唑 P |
Studies of nucleophilic displacements of nicleophilic agent of nitrogen on 2-methylsulphonyl-5-(3,4,5- trimethoxyphenyl)-1,3,4-oxadiazole |
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Abstract: | In this paper, 2-methylsulphonyl-5-(3,4,5-trimethoxyl- phenyl)-1,3,4-oxadiazole have been prepared and their subsequent transformations with a variety of nucleophilic reagents have been studied. Whereas the 2-methylsulphonyl- 5-(3,4,5-trimethoxylphenyl)-1,3,4-oxadiazole derivatives have been obtained from 2-mercupto-5-(3,4,5-trimethoxylphenyl)- 1,3,4-oxadiazole through methylation and subsequent oxidation with KMnO~4. Their structural proofs were based on elemental, IR, ^1H NMR, and MS analyses. The compounds 4 (2.0×10^-^4 mol·L^-^1) were preliminary screened for antibacterial activity against Bacillus Substilis and Escherichia Coli. |
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Keywords: | HYDRAZIDE TETRAZOLE P NUCLEOPHILIC REAGENTS |
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